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Investigators:
Emily Schroeder , Georgeta Vaidean , Eric Whitsel , Gerardo Heiss
This study was designed and implemented by graduate students in
the UNC Department of Epidemiology to determine the reliability
of and sources of error in electrocardiographic measures of heart
rate variability, T wave axis, and other markers of autonomic and
/ or ion channel dysfunction. Following training and certification
they examined healthy volunteers aged 45 to 64 years during serial
visits to the UNC Hospitals General Clinical Research Center. At
each visit, 12-lead, supine ECGs and six-minute, 3-lead, supine
heart rate recordings were obtained using the Atherosclerosis Risk
in Communities (ARIC) Study and the Multiple Risk Factor Intervention
Trial (MRFIT) protocols. Processing of standard, 12-lead ECGs and
6-minute heart rate recordings was provided by the Epidemiological
Cardiology Research (EPICARE) Center and the Ultrasound Reading
Center at the Wake Forest University Department of Public Health
Sciences.
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